Mutation and linkage disequilibrium in human mtDNA
نویسندگان
چکیده
منابع مشابه
Linkage disequilibrium in human populations.
Whereas the human linkage map appears on limited evidence to be constant over populations, maps of linkage disequilibrium (LD) vary among populations that differ in gene history. The greatest difference is between populations of sub-Saharan origin and populations remotely derived from Africa after a major bottleneck that reduced their heterozygosity and altered their Malecot parameters, increas...
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Linkage disequilibrium (LD) is bases of genomic selection, genomic marker imputation, marker assisted selection (MAS), quantitative trait loci (QTL) mapping, parentage testing and whole genome association studies. The Particular alleles at closed loci have a tendency to be co-inherited. In linked loci this pattern leads to association between alleles in population which is known as LD. Two metr...
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There is extensive evidence from model systems that disrupting associations between co-adapted mitochondrial and nuclear genotypes can lead to deleterious and even lethal consequences. While it is tempting to extrapolate from these observations and make inferences about the human-health effects of altering mitonuclear associations, the importance of such associations may vary greatly among spec...
متن کامل‘ ‘ Linkage disequilibrium in human populations , ’ ’ by Christine
MEDICAL SCIENCES. For the article ‘‘Linkage disequilibrium in human populations,’’ by Christine Lonjou, Weihua Zhang, Andrew Collins, William J. Tapper, Eiram Elahi, Nikolas Maniatis, and Newton E. Morton, which appeared in issue 10, May 13, 2003, of Proc. Natl. Acad. Sci. USA (100, 6069–6074; First Published April 29, 2003; 10.1073 pnas.1031521100), due to a printer’s error, the last three col...
متن کاملHuman Prehistory: The Message from Linkage Disequilibrium
The vast amount of information being gathered about human DNA sequence variation raises the question of what these data can tell us about events in our past. A new way has been found by which patterns of linkage disequilibrium can be used to detect the effects of natural selection in human prehistory.
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ژورنال
عنوان ژورنال: European Journal of Human Genetics
سال: 2001
ISSN: 1018-4813,1476-5438
DOI: 10.1038/sj.ejhg.5200735